Frontline Plus for Dogs Flea and Tick Treatment, 3 Doses This Frontline Plus Flea and Tick Treatment has been trusted by veterinarians for flea and tick control for dogs for nearly 20 years. Made with two tough killing ingredients, fipronil and (S)-methoprene, one to kill adult fleas and ticks and the second to kill flea eggs and larvae. This fast-acting, long-lasting protection provides flea and tick control for dogs and puppies. This Frontline Plus for dogs is simple to give, so your dog can be protected right away. It has a simple application process for your convenience.