Colace 2-in-1 tablets provide two ingredients in one safe, gentle, and dependable laxative to gently soften and move along hard and painful stool for a number #2 that’s easy to do. Colace is the #1 doctor recommended stool softener brand and Colace docusate sodium stool softener has been trusted by doctors and patients for over 65 years for occasional constipation (irregularity) relief. Colace 2-in-1 relieves many symptoms of occasional constipation, including straining during bowel movements, hard, dry stools, and infrequent or irregular bowel movements.